Tried changing some things to try and get Alinco programming software to break.
Prolific serial driver 22.214.171.124 works best. This is confirmed on the web on quite a few sites, for other cables and sofrware.
An earlier (V2.0 from 2005) also worked.
Driver V3.3 appeared to be OK in Device Manager but gave a Port Error.
Driver V3.4 installed but Device Manager said it could not start.
I had 3 different versions of the programming software installed, but only 2 worked. Both of these were from 2010, the oldest (2009) version gave an error message when trying to read (not Port Error), this could have been a mismatch of firmware or different regional model.